Curr Biol：分散焦虑可有效缓解疼痛感

全因，刊登在国际著名周报Cell的子刊Current Biology上的一篇科学研究报告指出有，为了让精神状态妨碍（分心）的新方法可以使得瘙痒减轻，然而这种瘙痒缓解减轻的效应并不显出有在头部。这项科学研究找到是基于适用高质量的骨髓机能性核磁共振光学关键技术（fMRI关键技术），对人们由于零下造成了的瘙痒技术水平进行科学研究，科学研究阐明，精神状态妨碍确实可以在当所在之处瘙痒处理早期抑制瘙痒信号的起源于。来自汉堡-埃钖多夫大学该学院的科学研究者Christian Sprenger表示，这种周期性并不仅仅是一种精神状态周期性，而是一种知名的神经机制，可以降较差从脊柱攀升至小脑Senior地带的瘙痒信号。

这种效应涉及到了内源性的类杂质，这种杂质产生自小脑，在减轻瘙痒的过程当中扮演着极为重要角色。科学研究人员让组织者分别完成一个恰当或者一个都能的记忆性任务，需要他们记住纸条的注释内容，同时给组织者腿上施以零下。进行都能任务的组织者变得心烦意乱时，他们会感到小得多的瘙痒，通过fMRI关键技术阐明出有这些组织者的脊柱地带活性变得非常较差，fMRI通常是用来测定小脑活性的改变。

Sprenger和他的同事然后减法了实验，这次他们给予组织者一种药物-钠洛酮（抗休克的令人满意药物，可以阻挡抗抑郁药的效应）或者都可的盐水流经，结果显示，相对于只流经都可盐水的组织者，适用抗抑郁药拮抗剂的组织者由于注意力分散，造成了的瘙痒缓解降较差了40%，因此声称内源性的扮演着极为重要作用。

科学研究者的找到阐明了精神状态过程可以险恶地改变人们的瘙痒经历，并且对于诊疗也有最极为重要的含义。科学研究者表示，我们的科学研究找到给瘙痒性疾病疗程提供了思维行为疗程的新方法。（生物谷：T.Shen编译）

doi:10.1016/j.cub.2012.04.006PMC:PMID:

Attention Modulates Spinal Cord Responses to Pain

Christian Sprenger1, , , Falk Eippert1, Jürgen Finsterbusch1, Ulrike Bingel1, 2, Michael Rose1, Christian Büchel1

Reduced pain perception while being distracted from pain is an everyday example of how cognitive processes can interfere with pain perception [ [1], [2], [3], [4] and [5]]. Previous neuroimaging studies showed distraction-related modulations of pain-driven activations in various cortical and subcortical brain regions [ [6], [7], [8], [9], [10] and [11]], but the precise neuronal mechanism underlying this phenomenon is unclear. Using high-resolution functional magnetic resonance imaging of the human cervical spinal cord in combination with thermal pain stimulation and a well-established working memory task [12], we demonstrate that this phenomenon relies on an inhibition of incoming pain signals in the spinal cord. Neuronal responses to painful stimulation in the dorsal horn of the corresponding spinal segment were significantly reduced under high working memory load compared to low working memory load. At the individual level, reductions of neuronal responses in the spinal cord predicted behioral pain reductions. In a subsequent behioral experiment, using the opioid antagonist naloxone in a double-blind crossover design with the same paradigm, we demonstrate a substantial contribution of endogenous opioids to this mechanism. Taken together, our results show that the reduced pain experience during mental distraction is related to a spinal process and involves opioid neurotransmission.